This lipid's structure influences the ability of LNPs to successfully deliver their contents and advances mRNA therapies for vaccines and gene editing. Nanoparticles have transformed how mRNA ...

In previous research, Swingle conducted a successful proof-of-concept study that examined a library of lipid nanoparticles (LNPs), the delivery molecules that helped get the mRNA of the COVID ...

The latest success from these UT Health San Antonio and UC Berkeley scientists is a study published in August 2024 in Nature Nanotechnology that suggests a lipid nanoparticle-mRNA structure ...

More information: Ahmed E. I. Hamouda et al, Intratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21, IL-7, and 4-1BBL induces systemic anti-tumor immunity, Nature ...

Engineers have modified lipid nanoparticles (LNPs) -- the revolutionary technology behind the COVID-19 mRNA vaccines -- to ... BBB is difficult because the structure has evolved to keep out ...

The other part is a lipid nanoparticle to deliver the mRNA cargo. These fatty bubbles are bioengineering wonders with multiple components. Some of these grab onto the mRNA; others stabilize the ...

The short length of peptides allowed the researchers to attach many to a single lipid nanoparticle. (Image: Emily Han) Crossing the BBB is difficult because the structure has evolved to keep out ...

The peptide-functionalized lipid nanoparticles ... because the structure has evolved to keep out virtually any dangerous or foreign molecules, including most medicines; mRNA molecules are too ...

Alternatively, researchers can also modify the chemical structure of the mRNA cap found at the ... this space have focused on the use of lipid-based nanoparticles. These particles are inherently ...

Crossing the BBB is difficult because the structure has evolved to keep out virtually any dangerous or ... Reference: Han EL, Tang S, Kim D, et al. Peptide-functionalized lipid nanoparticles for ...