Platelets are a potent source of growth factors, and are present in the injured liver. [19] Potentially important platelet mediators include platelet-derived growth factor (PDGF), TGF-beta 1 ...

Among these signals, the TGF-β and HIPPO pathways are critical, functioning as tumor suppressors and regulating liver development and regeneration. The review focuses on these pathways' interplay ...

Sai Wang and several collaborators, how ECM1 acts as a "gatekeeper" in a healthy liver to suppress the activation of the signaling molecule transforming growth factor-β (TGF-β). TGF-β plays a ...

Sirnaomics studied intravenous doses of the combination of the TGF-β1/COX-2 siRNAs in STP707 in a hepatocellular carcinoma model. The study found the oligonucleotides reached the liver and caused ...