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ZCCHC4通过ROS/c-myc轴调控食管癌进展和顺铂耐药
说明清除 ROS 能够逆转 ZCCHC4 敲低对 ESCC 细胞增殖和凋亡的影响。 4.6 过表达 ZCCHC4 促进食管癌细胞增殖、抑制凋亡并增加顺铂耐药性 在 ZCCHC4 过表达细胞系中,c - myc 表达增加,p - H2A.X 减少,ROS 水平降低。细胞增殖能力增强,对顺铂的耐药性增加,细胞周期中 G0 ...
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