撰文 | 冉茂双 责编 | 周叶斌MYCN的异常表达与多种人类癌症的肿瘤发生密切相关，其中MYCN扩增是高危神经母细胞瘤 (NB) 的主要遗传驱动因素，也是临床上最强的独立不良预后因素。MYCN基因编码致癌转录因子N-Myc在正常神经前体细胞中泛素化 ...

研究针对 MYCN 扩增型神经母细胞瘤治疗难题，探究 FAM13A 与 N-Myc 作用，发现 FAM13A 或为潜在治疗靶点。 研究背景：攻克难题，探索新靶点 神经母细胞瘤（Neuroblastoma，NB）是一种常见于婴幼儿时期的神经内分泌肿瘤，起源于神经嵴细胞。它在儿童癌症相关死亡中占 ...

MYC homology box is a region that is highly conserved between MYC, MYCN and MYCL1, unless otherwise stated 95,113. This domain is essential for primary REF co-transformation with activated Ras.

However, dysregulation of MYC, such as amplification of MYCN, is associated with tumorigenesis, especially for neuroblastoma. MDM2, on the other hand, is one of the most frequently studied ...

However, dysregulation of MYC, such as amplification of MYCN, is associated with tumorigenesis, especially for neuroblastoma. MDM2, on the other hand, is one of the most frequently studied ...