研究人员分析 470 例 ALS 患者全外显子测序数据，发现 MAPT 突变与 ALS 相关，该成果意义重大。 探索神经退行性疾病的神秘关联：MAPT 突变与肌萎缩侧索硬化 在神经科学的领域中，肌萎缩侧索硬化（Amyotrophic Lateral Sclerosis，ALS）和额颞叶痴呆（Frontotemporal Dementia ...

研究人员针对额颞叶痴呆（FTD）等疾病，解析 MAPT 突变 V337M 和 R406W 的 tau 丝结构，发现其呈阿尔茨海默折叠。 在神经退行性疾病的研究领域，额颞叶痴呆（FTD）和阿尔茨海默病（AD）是最常见的早发性痴呆类型。FTD 以行为改变为首发症状，随后才出现认知障碍 ...

Researchers at Mayo Clinic in Florida, University College London in England and collaborators worldwide have established the Pick's Disease International Consortium to study a specific MAPT gene ...

We have developed a series of targeted mice expressing frontotemporal-dementia-causing mutations in the humanized MAPT gene to investigate the earliest stages of tauopathy." Tau ...

Researchers from Voyager Therapeutics Inc. presented preclinical activity data of VY-1706, a blood-brain barrier (BBB)-penetrant gene therapy comprising an adeno-associated virus serotype 9 capsid ...

Their findings uncovered that seven genes (MAPT, TNFSF12, GZMB ... By combining insights on specific gene targets, brain regions linked to aging, and existing clinical trial data, the researchers ...