Researchers at Mayo Clinic in Florida, University College London in England and collaborators worldwide have established the Pick's Disease International Consortium to study a specific MAPT gene ...

We have developed a series of targeted mice expressing frontotemporal-dementia-causing mutations in the humanized MAPT gene to investigate the earliest stages of tauopathy." Tau ...

Their findings uncovered that seven genes (MAPT, TNFSF12, GZMB ... By combining insights on specific gene targets, brain regions linked to aging, and existing clinical trial data, the researchers ...

Researchers from Voyager Therapeutics Inc. presented preclinical activity data of VY-1706, a blood-brain barrier (BBB)-penetrant gene therapy comprising an adeno-associated virus serotype 9 capsid ...