In contrast, diclofenac has a peripheral analgesic action in this test ... whereas LPS-induced COX-2 is insensitive to paracetamol inhibition. The mechanisms of induction and possibly the ...
Actually, the mechanism of paracetamol as a painkiller has always ... and reducing fever – and its action can be enhanced by taking it with caffeine. We have previously reported on the potential ...
BMC Clin Pharmacol. 2010;10(10):1-12. Taken together these differing modes of action and related therapeutic effects suggest that ibuprofen and paracetamol may complement each other and improved ...