Researchers try multiple means to get high-quality membrane proteins for X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy studies. As much as 30% of human genes code for ...

Such proteins have prominent roles in almost ... he designed for the project to be a general accelerator of membrane-targeting drug design. "Before, the process basically involved two people ...

Many drug and antibody discovery pathways focus on intricately folded cell membrane proteins: when molecules of a drug ...

Most of these processes are performed by proteins embedded within the cellular membrane. While some proteins only cross the membrane once, many do so several times, like a thread being woven into ...

reveals a new signaling mechanism that could be exploited for delivering other drugs. Many malignant cancers overexpress a protein called P-cadherin, which is embedded in the cell membrane.

Adhesion G protein-coupled receptors are a large class of membrane proteins that detect chemical and mechanical stimuli in the body. The GAIN domain plays a central role in the activation of adhesion ...