Methotrexate is thought to act via folate-pathway enzymes; however, studies seeking associations between patient responses to methotrexate and single nucleotide polymorphisms (SNPs) in folate ...

In February 2004, pemetrexed disodium (Alimta; Eli Lilly), an anticancer drug that targets folate-dependent reactions ... The utility of methotrexate has led to considerable efforts to develop ...

Some people who take methotrexate will need to take folic acid supplements because the medication can diminish the amount of ...

Predictors of Variability/Individualization of Therapy: Is it Possible? In an attempt to enhance the prediction of clinical outcomes on MTX, and even individualize ...

Int J Clin Rheumatol. 2013;8(1):123-135. ML Becker's work was supported by the Katharine B Richardson Grant, the Children's Mercy Young Investigator Award, the Paul Henson Immunology Research ...