Decades ago, psoriasis was thought to be driven by the ... explained the efficacy of immunosuppressive therapies, such as methotrexate and cyclosporine, and provided the rationale for targeting ...

When psoriasis is refractory to topical therapy and phototherapy, or skin coverage is too extensive, systemic agents are used 1. Conventional oral systemic agents — retinoids, methotrexate ...

People with psoriasis should continue their current biologic or immunosuppressive therapy when they are vaccinated. The only exception is in people age 60 and older who take methotrexate.

About 1.3 million people in the UK are on methotrexate for conditions such as rheumatoid arthritis and psoriasis. It stops flare-ups, but can make the body less able to fight infections or respond ...