Fluorescent imaging studies revealed that chronic stress activates what’s known as the NF-κB pathway, already known to regulate NLRP3 inflammasome activity, in microglia found in the mouse hippocampus ...

Specifically, we pharmacologically manipulated a molecular complex called the NLRP3 inflammasome. It is found in microglia, which are the immune cells of the brain," says Dr. Róisín McManus ...

Specifically, we pharmacologically manipulated a molecular complex called the NLRP3 inflammasome. It is found in microglia, which are the immune cells of the brain," says Dr. Róisín McManus ...

The ‘NLRP3 inflammasome’ is like a control switch. In Alzheimer’s disease, its activation triggers an inflammatory response ...

The “NLRP3 inflammasome” is like a control switch ... NLRP3 not only reduces neuroinflammation, but also helps microglia clear the harmful amyloid-beta deposits, a process called phagocytosis.

Scientists from DZNE, University Hospital Bonn, and the University of Bonn have found new evidence that reducing brain inflammation could help treat Alzheimer’s disease. Their research, published in ...

Specifically, we pharmacologically manipulated a molecular complex called the NLRP3 inflammasome. It is found in microglia, which are the immune cells of the brain." Dr. Róisín McManus ...

Then, in 2001, researchers in California discovered the genetic explanation for his disease: a mutation in a gene called CIAS1 (since renamed NALP3 and then NLRP3), which was later found to cause the ...