In 2004, fifty years after Novikoff and de Duve observed lysosomes under the electron microscope, Noboru Mizushima and colleagues at the Tokyo Medical and Dental University tracked the formation ...

Plastic nanoparticles (green), visible under a microscope, co-mingling with protein aggregates(red) in neuronal lysosomes (blue). Typically, concentrations of the protein aggregates are so small ...