In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell ...

In this new study, the researchers reveal the structure of U11 snRNP – one of the five subunits of the minor spliceosome, which initiates the intron selection process. Spliceosomes help cells remove ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell ...

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

We study regulation of gene expression by the minor spliceosome. This parallel pre-mRNA splicing machinery functions during the nuclear RNA processing phase and regulates cellular mRNA levels. We ...

The vast majority of introns are removed by the major spliceosome, a 60 S complex containing ... Within this complex, intron excision occurs in two steps, each a single transesterification reaction.

The spliceosome (not shown) was known to catalyze two chemical reactions (black arrows) in a two-step process (green arrows labeled 1 and 2) that splice the exons together and removes the intron ...