Vijg describes this genome and discusses the significance of DNA damage to mitochondria, which may be an important signaling factor in the aging process. A leading theory of aging, which he ...

proposing that mitochondria are the source of the free radicals. As Harman’s free-radical theory of aging took hold, it fueled research into cancer, Alzheimer’s and many other diseases.

(Mitochondrial DNA, in contrast ... Key Concepts in the Genetic Theory of Aging The key concepts in genetics and aging include several important concepts and ideas ranging from telomere shortening ...

During the healthy aging process, the microbial-derived metabolite phenylacetylglutamine (PAGln) drives host cellular senescence by inducing DNA damage and mitochondrial dysfunction via ...