This paper presents the important finding that BNIP3/NIX, a mitophagy receptor, and its binding to ATG18 are required for mitophagy during muscle cell reorganization in Drosophila. Although the ...

A recent award from the National Institute of General Medical Sciences of the National Institutes of Health will aid Wayne State University researchers in their exploration of the underlying biology ...

However, precise mechanisms underlying mitochondrial dysfunction ... Normally, damaged mitochondria in TILs are removed through a process called mitophagy. However, mitochondria transferred ...

The five-year, $1.8 million grant, “Mechanisms of Mitophagy in Tissue Health and Homeostasis,” will be led by Ryan Insolera, Ph.D., assistant professor of ophthalmology, visual and anatomical ...

Autophagy is a process used by cells as a recycling system to transport and break down organelles and other cytosolic components, which become enveloped in a membrane called the autophagosome.

Cells respond to pathogenic and extrinsic stresses through mechanisms that safeguard mitochondrial ... showed exacerbated mitochondrial enlargement and mitophagy impairment compared to Drp1 ...