In this study, we demonstrated that insufficient erythropoiesis in an immunocompetent acute myeloid leukemia (AML) murine model was due to reduced proliferation of megakaryocyte erythroid ...

Notably, this approach did not damage healthy early blood stem cells or immune cells in human and AML mouse models. When leukemia infiltrates the bone marrow, it generates CD38-positive abnormal ...

We combine genetic mouse models and pre-clinical mouse models using patient samples to study genes involved in pediatric (acute lymphoblastic leukemia) and adult (chronic myeloid leukemia and acute ...

More information: Heejin Jun et al, CD13-targeting and TRAIL-displaying protein nanoparticles effectively induce apoptotic ...

Triplet Regimen Yields Promising Response in Advanced-Phase Chronic Myeloid Leukemia Sep. 17, 2024 — According to new research, 80% of patients with previously untreated or relapsed/refractory ...

The team identified a specific population of immune cells that play a critical role in successful treatment of relapsed acute myeloid leukemia (AML). A research team from Columbia Engineering and ...

In a mouse corneal angiogenesis assay ... relationship between lymphatic draining function and disease processes. Myeloid lineage cells, including macrophages, dendritic cells, osteoclasts ...

Dana-Farber Cancer Institute researchers have identified factors that determine whether donor lymphocyte infusion (DLI), a standard therapy for patients with acute myeloid leukemia (AML ...