St. Jude researchers reveal that moderate levels of mitochondrial DNA mutations boost leukemia growth by increasing metabolic plasticity, while high mutation levels shut down tumor development. They ...

But while constraint models have been highly effective for identifying disease-causing variants in the nuclear genome, they ...

The energy factories in our cells contain their own genes, and genetic mutations in them can cause deadly inherited diseases. These oblong-shaped organelles, or mitochondria, translate genes into ...

However, mechanistic studies to support the conclusion that mitochondrial function is increased in the tumours remain incomplete and would benefit from experiments that would directly interrogate ...

The research is also featured in a News and Views piece. Clinical specimens from melanoma and non-small-cell lung cancer patients were analyzed for mtDNA mutations. Mitochondrial transfer was studied ...

Mitochondria are critical for cellular homeostasis, regulating bioenergetics, redox balance, Ca2+ signaling, and cell death. Mitochondrial Ca2+ (Ca2+mito) plays a dual role in physiological processes ...

The point mutation in the mitochondrial genome tRNALeu (A3243G) is associated with the syndrome of mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes (MELAS). We report a ...

Researchers have discovered several mutations in the mitochondrial DNA of Drosophila that affect male lifespan and rate of aging, but have no effect on aging in females, according to a study published ...

The data described above, however, support a direct or indirect role for several of these genes in both mitochondrial function and the cellular response to oxidative stress.