Gutierrez’s team infected macrophages generated from human induced pluripotent stem cells with Mtb. Using CRISPR-Cas9 tools, they deleted ATG7 or ATG14 from macrophages and observed increased Mtb ...

Through the process of antigenic variation, P. falciparum expresses different versions of it and escapes immune recognition. 3) Inside macrophages, Mycobacterium tuberculosis dodges intracellular ...

More information: Fatima A. H. Al-Jaberi et al, Reduced vitamin D-induced cathelicidin production and killing of Mycobacterium tuberculosis in macrophages from a patient with a non-functional ...

To increase efficacy, the researchers delivered the enzymatic drug inside of host macrophages where mycobacteria grow. In laboratory experiments, the drug was effective against M. tuberculosis and ...

The PPE2 protein of Mycobacterium tuberculosis is secreted during infection and facilitates mycobacterial survival inside the host. The potential mechanism of the progression from latent to active ...

The current tuberculosis (TB) vaccine Mycobacterium bovis bacillus Calmette-Guérin (BCG) is the most widely used vaccine worldwide, but it does not prevent the establishment of latent TB or ...

Working toward more effective tuberculosis (TB) vaccines, researchers at Weill Cornell Medicine have developed two strains of mycobacteria with "kill switches" that can be triggered to stop the ...

Engineered Mycobacterium tuberculosis triple-kill-switch strain provides controlled tuberculosis infection in animal models. Nature Microbiology , 2025; 10 (2): 482 DOI: 10.1038/s41564-024-01913-5 ...

The infectious disease tuberculosis is caused by the bacterium Mycobacterium tuberculosis ... the so-called macrophages, in ...