由加拿大西安大略大学研究人员领导的一项新研究首次确定了一个因素，该因素可能会影响人类免疫缺陷病毒（HIV）在细胞内潜伏的口袋在治疗时收缩的速度。相关研究结果发表在 Lancet Microbe 杂志上。 HIV感染很难治愈，部分原因是这种病毒能够创造“潜伏的病毒库”，在那里它隐藏在细胞内处于休眠状态，不会被检测到。

A new study led by Western researchers is the first to identify a factor that could influence how fast the pocket where human ...

相关研究结果于2025年1月30日在线发表在Nature期刊上，论文标题为“HIV immune evasin Nef enhances allogeneic CAR T cell potency”。这项研究是在Michel Sadelain博士的 ...

But how do the virally infected cells protect themselves long enough to manufacture more HIV virions? A recent paper in Nature suggests that Nef may be part of the answer. There has been some ...

Gag (495 amino acids) is also the most immunogenic of the HIV proteins, followed by Pol (1,001 amino acids) and Nef (206 amino acids). The most conserved (that is, which shows the least sequence ...

An effective HIV-1 vaccine must therefore elicit antibodies that can neutralize many variants of the virus. While broadly neutralizing antibodies (bnAbs) have been isolated from HIV-1 infected ...

Fox Chase Chemical Diversity Center Inc. and University of Pittsburgh have jointly described new proteolysis targeting chimeras (PROTACs) consisting of Nef (HIV-1)-targeting moiety covalently linked ...

tuberculosis EsxH-EsxG complex also disturbs the process of antigenic presentation via the MHC-II molecule. 6) To stay hidden inside lymphocytes, HIV-1 expresses viral factors such as the negative ...