为探究 1 型神经纤维瘤病（NF1）正常组织中是否存在 “二次打击”，英国研究人员开展测序研究，发现 NF1 在正常组织中有二次突变且受正选择，有助于理解该疾病癌症表型。 一、研究背景 在生命的微观世界里，癌症的发生机制一直是科学家们努力探索的谜题。

This included three cultures from non-tumor nerve of subjects with NF1, leading to matched heterozygous SC lines for two of the subjects whose NF1-null Schwann cells also immortalized (ipNF95.11b ...

It’s important to know that an accurate diagnosis of NF1 can only be made by a physician with expertise in the diagnosis and treatment of neurofibromatosis. Because people with NF1 often have multiple ...