Chronic somatic pain results from inflammatory responses ... In turn, GluRs can be divided into three subtypes: N-methyl-d-aspartate (NMDA) receptors, kainate receptors, and AMPA ((2-aminomethyl ...

XW10508 is a glutamatergic NMDA antagonist and AMPA activator designed for the treatment-resistant depression and chronic pain. Unlike Spravato, XW10508 is an oral therapy that slowly releases ...

Chronic hypofunctioning of the NMDA receptor, along with the persistent release of excitatory neurotransmitters, can lead to neurodegeneration. Depending on the degree and duration of NMDA ...