相关研究成果以《镁离子对NMDA受体多重调控机制的结构基础》为题，发表在《神经元》（Neuron）上。研究工作得到科技创新2030-重大项目、国家自然 ...

NMDA (N-methyl-D-aspartate ... In recent years, glutamate and GABA receptors have been shown to move rapidly around the neuron so as to alter the number and composition of receptors that are ...

Here, we explored how NMDARs signal in tLTD. We found that, regardless of frequency, L5 PC→PC tLTD relies on the non-ionotropic preNMDAR signaling pathway mediated by JNK2, which helps to resolve the ...

Now ketamine, a glutamatergic NMDA receptor antagonist, may provide a mechanism that could link these pathways. Figure 1: A schematic of how ketamine may lead to an overall excitation in the cortex.

The new approach described in Cell Reports works by targeting a specific molecular subunit of "NMDA" receptors that ...

The new approach described in Cell Reports works by targeting a specific molecular subunit of "NMDA" receptors that ... altered protein synthesis in the neuron and caused a physical shrinking ...