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优化培养条件提升 Neurturin 在 Rosetta-gami 菌株中的可溶性表达
研究人员利用 Rosetta-gami 菌株生产 Neurturin,优化条件后产量提升 8.6 倍,助力神经退行性疾病治疗。 神经营养生长因子 Neurturin 被视为神经退行性疾病潜在的治疗或逆转药物。虽然大肠杆菌是重组蛋白表达的合适宿主,但在该菌株中生产含有二硫键的蛋白质(如 ...
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