近年来，自然杀伤细胞（NK细胞）正逐渐成为基因工程改造的新宠。这类天然免疫细胞与T细胞截然不同，能广泛识别并直接击杀肿瘤细胞。在外周血中，约90%的NK细胞为CD16+CD56dim亚群，它们通过分泌穿孔素和颗粒酶等因子，展现出强大的细胞毒性。而约10%的CD16-CD56bright亚群则通过分泌多种细胞因子来调节免疫反应，通常聚集在淋巴组织中。通过识别恶性肿瘤细胞，NK细胞可以迅速被激活并执行 ...

NK cells recognize cell-bound antibodies via CD16A (FcγRIIIA) to mediate antibody-dependent cellular cytotoxicity (ADCC). Potentiating therapeutic mAb-mediated CD16 activation of NK cells is an ...

研究人员为了探究 CRC 微环境中 NK 细胞表型变化与重要免疫检查点表达之间的关系，评估结直肠癌间质中 CD16 bright CD56 negative （CD16 + CD56-）NK 细胞相关免疫检查点的表达水平，开展了一系列实验。研究人员从西安大兴医院病理科 2020 年 1 月至 2022 年 1 月诊断为 CRC ...

The bispecifics are differentiated through their targeting of NKp46 to engage NK cells, rather than the CD16 and NKG2D receptors targeted by other bispecifics. Importantly, NKp46 expression is ...

A new area of cancer immunotherapy is enhancing therapeutic mAb-mediated CD16 activation of NK cells. CAR-NK cells containing multi-specific molecules made up of relatively stable CD16 and other ...

Although NK cells have natural antibody-binding molecules such as CD16, their ability to hold onto antibodies long-term is inferior compared with CD64. To improve antibody binding, the researchers ...

Immunotherapy. 2011;3(9):1075-1086. MIP-1β release has also been observed for CD56 neg NK cells from patients with HCV infection. The above results suggest that the aberrant CD56 neg NK subset ...

SAR443579 (also known as IPH6101) is a tri-functional NKp46/CD16-based anti-CD123 NK cell engager – described as a first-in-class therapy – that has now advanced into a phase 2 programme.