Nonribosomal peptides (NRPs) are a diverse class of natural products synthesized by nonribosomal peptide synthetases (NRPSs), which are large, modular enzymes. Unlike ribosomal peptides ...

What is it? As the name suggests, nonribosomal peptide synthesis (NRPS) generates polypeptides sans ribosome. The resultant peptides, generally short oligomers of two to perhaps 48 residues, are not ...

New research published today in Nature Communications, describes how CRISPR-Cas9 gene editing can be used to create new nonribosomal peptide synthetase (NRPS) enzymes that deliver clinically important ...

The molecular machines that Pistofidis and Schmeing studied are called nonribosomal peptide synthetases, or NRPSs. They build some of the most important compounds in current health care and ...

Much of the natural product chemical diversity observed in nature is attributed to versatile non-ribosomal peptide synthase (NRPS) and polyketides synthetase (PKS) biosynthetic pathways. We have shown ...

While analyzing the Rhodococcus genome, the MIT researchers were surprised to find close to 100 genes for nonribosomal peptides, and 30 clusters of genes for polyketides, two major classes of ...