Historically, most people started HIV treatment with two drugs from the NRTI class combined with either one NNRTI, one protease inhibitor or one integrase inhibitor – hence, ‘triple therapy’.

Many drugs and their metabolites are excreted through ... prescribed nucleoside reverse transcriptase inhibitor (NRTI). The combination of didanosine with boosted protease inhibitors was ...

NRTI-resistance mutations & their mechanism of drug resistance M184V/I is the most prevalent mutation. M184V alone confers high-level resistance to both lamivudine and emtricitabine. A series of ...

Promising drug classes include integrase and entry inhibitors. Possible intraclass NRTI sequencing strategies. The backbones TDF/FTC or ABC/3TC could be sequenced with AZT/3TC or d4T/3TC.

There is a limited number of studies on interactions between GHB and anti-HIV drugs. These studies reported higher exposure to GHB, which may lead to higher levels of GHB. Due to the close relation ...