mTOR was shown to limit the production of pro-inflammatory cytokines by inhibiting nuclear factor-κB (NFκB) activity, whereas it promoted IL-10 production by activating signal transducer and ...

In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...