Until now, the most common ways to make these modified nucleoside analogs required a process taking anywhere from nine to 16 steps. The new approach requires just five steps.

Many of the nucleoside antibiotics exhibit their activity only after conversion into their nucleotide form (mono- or triphosphate) once inside the cell. A number of nucleoside analogues which were ...

Deoxynucleoside analogues such as 5-aza-2-deoxycytidine (depicted by Z) are converted into the triphosphate inside S-phase cells and are incorporated in place of cytosine into DNA. Ribonucleosides ...

[7] Stavudine (d4T), like zidovudine, is a thymidine analogue. It is preferentially phosphorylated and exerts more potent antiviral activity in activated rather than resting cells. Stavudine was ...

2007;27(8):509-531. Antiretroviral drugs (ARVs) can be divided into four different classes according to their modes of action: nucleoside or nucleotide reverse transcriptase inhibitors (NRTIs or ...