Failure to control the cell cycle adequately can lead to diverse life-threatening diseases such as cancer. Figure 2: Deregulation of p27 protein turnover contributes to tumorigenesis.

Several pieces of evidence indicate that the tumour suppressor p27 (encoded by CDKN1B) has other functions beyond its role as a cell-cycle inhibitor. James Roberts, Arnaud Besson and colleagues ...

并通过K29-泛素链连接到p27，进而促进其自噬降解。通过敲低CUL1或阻断Neddylation，可恢复耐药细胞对索拉非尼的药物敏感性，为未来克服索拉非尼耐药提供了潜在策略。该成果发表于《Cell Biology and Toxicology》杂志。 在研究过程中，研究人员首先利用加权基因共 ...

One notable exception is the cyclin-dependent kinase inhibitor p27 Kip1. p27 is an inhibitor of the cell cycle, and thus a candidate tumor suppressor by birthright. But the homozygous loss or ...

AKT regulates the cell cycle by phosphorylating FoxO1 and decreasing its transcription of CDK inhibitors p21 and p27. AKT, protein kinase B; CDK, cyclin dependent kinase; FoxO1, forkhead box O1 ...