Recent work has discovered the role of the cyclin-dependent kinase (CDK)-binding protein Cks1 in degrading the CDK inhibitor p27 Kip1. This process is essential for DNA replication and is ...

Because of flexibility, the disruption of the p27 Kip1 –cyclin A–Cdk2 complex can proceed in a step-wise, segmental fashion, which likely provides a kinetic advantage for the overall process.

These include famous genes such as K-ras and p53. One notable exception is the cyclin-dependent kinase inhibitor p27 Kip1. p27 is an inhibitor of the cell cycle, and thus a candidate tumor ...