小胶质细胞是大脑的常驻免疫细胞，通过动态延伸分支持续监测脑环境，并与神经元相互作用以维持稳态。研究表明，小胶质细胞通过Gi蛋白偶联受体（Gi-GPCRs，如P2Y12）调控神经元活动，物理接触可抑制过度活跃的神经元或增强低活性神经元的功能。敲除小胶质细胞的P2Y12受体或通过百日咳毒素（PTX）抑制Gi信号会减少其动态监测 ...

冠状动脉粥样硬化性心脏病是指由于冠状动脉粥样硬化使管腔狭窄或闭塞导致心肌缺血、缺氧或坏死而引发的心脏病，统称为冠状动脉性心脏病或者冠状动脉疾病，简称冠心病，归属为缺血性心脏病，是动脉粥样硬化导致器官病变的最常见类型。为了预防心肌梗死，改善冠心病预后， ...

Background: Prasugrel is a novel third-generation thienopyridine P2Y12 receptor antagonist with more rapid, potent, and consistent platelet inhibition than clopidogrel. [23] Aim: Compare the ...

More potent DAPT strategies and oral anticoagulation were tied to worse outcomes and should be avoided, researchers say.

With no differences between single or dual antiplatelet therapy or anticoagulants at 6 months, an RCT is warranted for ...

P2Y12 receptor antagonists (clopidogrel, prasugrel, ticagrelor (Brilinta, AstraZeneca) and ticlopidine) are indicated in all STEMI cases unless urgent surgery is required. Clopidogrel can also be ...

New Delhi: Mylan Pharmaceutical has got approval from the Subject Expert Committee (SEC) functional under the Central Drug ...