1) of p53 programs p53 responses to stress ... However, the very same N terminus has to function as a transcription activation domain by recruiting general transcription factors and co-activators.

The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.

One such mechanism involves a protein called p53. Often dubbed the "guardian of the genome," this protein plays a pivotal ...

The aim of the present work was to establish an association between wood smoke exposure and lung cancer pathogenesis, and to analyze the effects of wood smoke on p53 and murine double minute 2 ...