MYC 在 ecDNA 上的扩增为肿瘤细胞提供了快速适应环境的机制，然而，高负荷的 ecDNA 会给癌细胞带来适应性成本，只有在特定的微环境条件下，ecDNA 才能为癌细胞提供生存优势。此外，研究还发现 p53 失活可能是 PDAC 中 ecDNA 形成的先决条件，但其具体形成机制仍需 ...

Blocking CKIα, CDK7, and CDK9 augments and synergistically stabilizes p53 and down regulates Myc and MCL1 promoting the rapid killing of leukemia cells as well as leukemic stem cells. Pre ...

Just over 25 years ago, MYC, the human homologue of a retroviral oncogene, was identified. Since that time, MYC research has been intense and the advances impressive. On reflection, it is ...

Through studies of proteins that regulate p53, scientists at St ... such as upregulation of MYC or other oncogenes," explains corresponding author Richard Kriwacki, PhD, St.

Researchers sought to evaluate differences in ctDNA profiles, use of targeted treatments, and overall survival between Black and White patients with metastatic breast cancer.

USPs such as USP22 and USP7 regulate key proteins like c-Myc and p53, influencing apoptosis in BC. Similarly, autophagy, a mechanism for cellular self-digestion, has a paradoxical role in BC ...