2025年2月18日，一篇新的研究论文发表在Oncotarget，第16卷，题为“端粒酶永生人类细胞中强大的p53表型和潜在的下游靶标”。 2025年2月18日，《Oncotarget》杂志第16卷发表了一篇题为“端粒酶永生化人类细胞中稳健的p53表型及潜在下游靶点”的研究论文。来自西德尼 ...

The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.

Figure 8: Regulation of ALDH3A1 and NECTIN4 by p53. Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz from the Sidney ...

A new research paper was published in Oncotarget, Volume 16, on February 18, 2025, titled "Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells.

Immune cells respond to threats based on the signals they detect. The p53 signaling pathway determines whether to repair damage or self-destruct to prevent cancer. Scientists have struggled to ...

Pan said. Dr. Pan said the protein p53, which has been shown by others to regulate amyloid-beta mediated neuron death seen in Alzheimer's disease, is also known to lose its function with cancer ...