the mechanisms by which p53 mediates cell-cycle arrest or apoptosis still remain unclear. There must be some way to specify which target genes of p53 are to be selected. The different serine ...

Wild-type p53 is often engaged in response to cellular damage, where it acts to regulate genes that promote cell-cycle arrest, apoptosis, senescence, differentiation, and autophagy (Figure 1). In ...

One group showed that p53 controlled the progression of the cell cycle, but it wasn’t clear how. 24 Guillermina Lozano entered the p53 field as a postdoctoral fellow in Levine’s lab in 1985 and ...

A new study has revealed that ferulic acid, a natural compound found in various plant-based foods, can significantly inhibit the growth and migration of colon cancer cells at different stages of ...

Ubiquitin-specific protease 7 (USP7) is involved in DNA repair and cell cycle progression and, due to its control over the ubiquitination of key proteins, may impact oncogenes like MDM2 and c-Myc, as ...

The aim of the present work was to establish an association between wood smoke exposure and lung cancer pathogenesis, and to analyze the effects of wood smoke on p53 and murine double minute 2 ...