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揭秘肺癌 “帮凶”:NF-κB/EAAT3 轴如何影响肺癌发展及潜在治疗新方向
在肿瘤生长实验中,给小鼠注射 GSH 抑制剂 BSO 后,肿瘤生长受到抑制,GSH 水平下降,同时肿瘤细胞对胱氨酸的摄取也减少。当用 QNZ 抑制 A549 和 PC9 细胞系中 P65 的表达时,细胞内 ROS 水平会随着 QNZ 浓度的增加而升高,用 GSH-MEE 中和 ROS 后,ROS 水平下降。
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