The cyclic nucleotide phosphodiesterase 4 (PDE4) regulates the hydrolysis of the second messenger cyclic AMP. cAMP is a major intracellular signalling mediator that directly affects the activity ...

Katalytic Therapeutics Inc. has divulged proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding moiety covalently linked to a phosphodiesterase PDE4-targeting ...

The assessment showed PALI-2108 was converted into its active PDE4 inhibitor form at a mean ... You can find a list of possible trading platforms here. Many will allow you to buy ‘fractional ...