Announcing a new publication for Acta Materia Medica journal. Phosphodiesterase-4 (PDE4), a member of the phosphodiesterase ...

In this study, Burgin et al. present crystal structures of inhibitor-bound PDE4, which show a previously unsuspected role for the regulatory domain UCR2 in controlling access to the enzyme's ...

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Katalytic Therapeutics Inc. has divulged proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding moiety covalently linked to a phosphodiesterase PDE4-targeting ...