它能通过促进感染细胞凋亡，诱导 IFN 刺激基因（ISGs）表达，像 2',5'- 寡腺苷酸合成酶 1（OAS1）、蛋白激酶 R（PKR）等，来抑制病毒复制。然而，IFN-α/β 是一把 “双刃剑”，它在对抗病毒的同时，也会导致肺上皮细胞的炎症损伤和凋亡。在流感病毒感染的小鼠中 ...

This cascade eventually results in the transcription of hundreds of genes, called IFN-stimulated genes, which include the genes that encode PKR, 2',5' oligoadenylate synthetases-RNaseL ...