The PLP1 gene is surrounded by LCRs of various sizes — these would make it easy for the fork to stall during replication and then for the lagging strand to associate serially with the DNA ...

One gene in particular, Plp1, had higher activity across multiple cell types. This gene codes for a component of myelin, the protective coating that envelops neurons. And it could have relevance ...

At least $65 million slated for 14 of 35 Alzheimer's disease research centers is in limbo, with funding expected to run out ...

The 'silent' X chromosome within female brains may not be so silent after all. A new study has found evidence in both mice ...

Oligodendrocytes (yellow) in the mouse brain, during an experiment testing the impact of the PLP1 gene on behavior. PLP1, when expressed in these cells in the hippocampus, improved cognition in old ...

Brain cells, or oligodendrocytes (green), in the hippocampus are marked with the GFP genetic marker in the mouse brain. These cells often deteriorate ...

Data in mice shows that aging female brains get a boost from genes on the second X chromosome to maintain memory and learning.

A test on lab mice may have helped scientists in California debunk a theory that part of the make up of genetics in females ...

Her group focused on one particular awakened gene, Plp1. It makes a protein that is part of myelin, a fatty sheath around nerve cells that “allows information to flow back and forth, like a ...

Scientists at the University of California, San Francisco (UCSF) may have uncovered a key reason why women tend to outlive men and maintain better cognitive function as they age. Their research ...

Then they measured gene expression in the hippocampus – a ... 22 genes that had ‘escaped’ silencing on the X chromosome, PLP1, stood out to the researchers. PLP1 helps build the neural ...