PML几乎仅在免疫缺陷状态下发生，历史上主要影响HIV患者，但随着高效抗逆转录病毒治疗（HAART）的出现，其发病率显著下降。然而，PML在使用生物制剂治疗的患者中逐渐受到关注，尤其是类风湿关节炎患者。RA是一种自身炎症性疾病，治疗通常需要多种免疫抑制 ...

PML is a typically fatal demyelinating central nervous system disease that occurs as a result of reactivation of the John Cunningham (JC) virus. The JC virus is a virtually ubiquitous infection ...

APL is a distinct subtype of myeloid leukaemia that in almost 100% of cases is associated with chromosomal translocations involving the PML and retinoic acid receptor α (RARA) loci, leading to ...