“We conducted further analysis on early and advanced stage colorectal cancer tissues and found that patients with advanced metastases were more likely to display PTEN LOH. The mutation could ...

Background: A 9-month-old boy with Proteus syndrome and a de novo germline mutation in the tumor suppressor PTEN was referred to a specialist centre for management. Over the first years of life ...

We thank Dr Patricia Dahia for the gift of PTEN cDNA and Dr Kristen Neville (supported by a grant from the Sydney Children's Hospital Foundation) for the provision of serum from age-matched normal ...

2001. Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression. Proc Natl Acad Sci 98: 11563-11568. Han G, Buchanan G, Ittmann M, Harris J, Yu X, DeMayo F, Tilley W, ...

Mitophagy is a selective form of autophagy via which the damaged mitochondria are cleared via the autophagy-lysosome pathway.

through deactivating PTEN. Importantly, the researchers found that PARK2 was significantly under-expressed across many tumour types. Widespread loss or reduced PARK2 in tumours correlated with poorer ...

or PTEN mutations last November. At one point, Novartis was predicting blockbuster sales for Piqray. Roche has said it intends to launch Itovebi in the US within the coming weeks, but hasn't yet ...

That may be because the non-biomarker group in the study included quite a high proportion of untested patients in whom PIK3CA/AKT1/PTEN status was unknown. Mutations in PIK3CA, AKT1, and ...