The study demonstrates that PDHX, a key component of the PDC, undergoes acetylation at lysine 488 by the acetyltransferase p300. This modification impedes the interaction between PDHX and ...

Working model: PDHX acetylation promotes tumor progression by disrupting PDC assembly and activating lactylation-mediated gene expression. GA, UNITED STATES, March 3, 2025 /EINPresswire / -- A ...