This image illustrates the chemical structure of a purine molecule ... GTP is also a substrate for the synthesis of RNA during transcription. Purine metabolism involves the synthesis and breakdown of ...

studying the structural properties of nucleic acids containing modified pyrimidine and purine bases and the design and synthesis of modified oligodeoxyribonucleotides for DNA-DNA and DNA-protein cross ...

ADSL plays a significant role in the de novo purine synthesis pathway, which is responsible for producing purine nucleotides from simpler molecules. When ADSL is deficient, it can result in the ...

While volunteering in a chemistry lab that could only offer her a dishwashing job ... Hitchings hypothesized that by preventing those purines from entering the metabolic pathway that leads to DNA ...

Most mutations that decreased antibiotic susceptibility were related to specific metabolic pathways. A MIC-increase to ...

Purine nucleotides are essential for cell growth and function as they serve as nucleic acid building blocks, signaling molecules, and energy carriers. Treatments that inhibit their synthesis offer a ...

These compounds inhibit the enzyme acetolactate synthase (ALS), which is crucial for the synthesis of branched-chain amino acids in plants, resulting in the selective elimination of weeds. Pyrimidine ...