This image illustrates the chemical structure of a purine molecule, highlighting the numbering of the carbon and nitrogen atoms. The purine structure consists of a pyrimidine ring (positions 1 to 6 ..

the mechanism of action in the suppression of inflammation differs from simply suppression of purine and pyrimidine metabolism, resulting in the inhibition of cellular proliferation. [31] MTX was ...

Pyrimidine analogs, such as 5-fluorouracil (5-FU) and gemcitabine, are used as chemotherapeutic agents to treat various types of cancer. These drugs interfere with DNA synthesis and replication, ...