Imbalances in pyrimidine biosynthesis can lead to various disorders, such as orotic aciduria and pyrimidine nucleoside phosphorylase deficiency. Some pyrimidine analogs, such as azidothymidine (AZT) ...

The purine structure consists of a pyrimidine ring (positions 1 to 6 ... autoimmune disorders, and infectious diseases. Purine analogues, such as fludarabine and cladribine, are used in the treatment ...

We are studying the incorporation of these analogues into DNA by polymerase enzymes in order to gain an insight ... studying the structural properties of nucleic acids containing modified pyrimidine ...