Cancer cells are known to favor aerobic glycolysis for energy production, a phenomenon termed the Warburg effect.

PDHX acetylation promotes tumor progression by disrupting PDC assembly and activating lactylation-mediated gene expression.

Combining LDHA inhibitors with glutaminase inhibitors ... (It's a by-product of water chlorination). It inhibits pyruvate dehydrogenase kinase (PDK), a key enzyme in glucose metabolism.

ACTIVATE-Kids is the First Study to Demonstrate Efficacy of an Oral Therapy for Children with PK Deficiency Who Are Not Regularly Transfused –– ...

MLN0128 (formerly known as INK128) is a novel, orally active mTOR kinase inhibitor currently in clinical development. Here, we evaluated MLN0128 in preclinical models of B-cell acute lymphoblastic ...

Endometriosis, a prevalent gynecological condition, is characterized by the growth of endometrial-like tissues outside the uterus, leading to severe pain and infertility in affected women. The ...