一种在MPXV A5L基因的mRNA中高度保守和稳定的G4，可作为病毒免疫显性蛋白表达的正向调控元件。RNA G4特异性解旋酶DHX36通过解旋G4抑制A5L蛋白表达。

为探究鼻咽癌（NPC）发展机制，中南大学的研究人员开展了相关研究，旨在揭示 NPC 发展的分子机制，寻找新的治疗靶点阐明 circCLASP2、DHX9 蛋白和 PCMT1 mRNA 之间的相互作用。。研究成果发表在《Molecular Cancer》上。

A highly conservative and stable G4 in MPXV, which acts as a positive regulatory element for viral immunodominant protein expression. RNA G4-specific helicase DHX36 inhibits A5L protein expression ...

By demonstrating that inhibiting G4 assembly could potentially prevent ... The researchers identified that G4s, four-stranded RNA structures that form in response to cellular stress, function ...