Both SGS3 and a viral suppressor of RNA silencing have now been shown to selectively bind 5′ overhang–containing dsRNA, implicating this RNA as a new intermediate in the RNA silencing pathway.

With recent technological advances, the molecular mechanisms of these RNA silencing pathways are becoming clearly defined, and their components are now being tested in clinical trials.

The natural RNAi mechanism can be directed by either short interfering RNA (siRNA) or microRNA (miRNA ... This promiscuous binding activity means that miRNA can act on many different mRNAs, ...

Ribonucleic acid, commonly known as RNA, is involved in many biological functions, and some, including gene silencing, are utilized to cure diseases. RNA has recently gained attention as a promising ...

Researchers at Purdue University have developed NuFold, a machine learning tool that predicts 3D RNA structures from ...

RNA-based therapeutics have rapidly emerged over the past decade, offering a new class of medicines that differ significantly from conventional drugs. These therapies can be programmed to target or ...

Ribonucleic acid, commonly known as RNA, is involved in many biological functions, and some, including gene silencing, are ...

More information: Wenxin Hu et al, Single-base tiled screen unveils design principles of PspCas13b for potent and off-target-free RNA silencing, Nature Structural & Molecular Biology (2024).

The search for a partner for zerlasiran is ongoing, according to Silence. In the meantime, the biotech will focus its ...

Ribonucleic acid, commonly known as RNA, is involved in many biological functions, and some, including gene silencing, are utilitized to cure ...