Exiqon LNA™ GapmeRs are powerful tools for loss of function studies of proteins, mRNA and lncRNAs. These single strand antisense oligonucleotides catalyze RNase H-dependent degradation of ...

The 5′ end of substrate mRNA dramatically affects its ability to be cleaved by RNase E: the rate constant for 5′-monophosphate RNA is more than an order of magnitude greater than that for RNA ...